Composition and Description
Composition: Each bottle contains: Sevoflurane USP 250 ml
The formulation contains sevoflurane (C4 H3 F7O), which is a halogenated general inhalation anaesthetic drug. Sevoflurane is a non-flammable, pleasant smelling, non-explosive and volatile liquid.
Sevoflurane is a clear, colourless and stable liquid containing no additives or chemical stabilizers. It is non- pungent, miscible with ethanol, ether, chloroform and petroleum benzene, and it is slightly soluble in water.
No discernible degradation occurs in the presence of strong acids or heat.
Sevoflurane is not corrosive to stainless steel, brass, aluminum, nickel plated brass, chrome plated brass or copper beryllium alloy.
Physical property constants of sevoflurane are as under:
|Gram molecular weight||200.0|
|Boiling point at 760mmHg||58.5°C|
|Refractive Index n20||1.2740 - 1.2760|
|Saturated Vapour pressure at 200C||157.0 mmHg|
|Odor||non-irritating, similar to ether|
|Stability in Moist Soda Lime at |
400C / 600C / 800C
|Purity by gas chromatography||99.975% or better|
Partition Co-efficients at normal body temperature:
|Blood :Gas||0.63 - 0.69|
|Olive Oil :Gas||47.2 - 53.9|
|Brain : Blood||1.7|
|Heart : Blood||1.78|
|Liver : Blood||1.85|
Mean Partition coefficients at 25°C – component/gas