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ADME Studies and Services

Adme Assays

ADME Screening Services

In vitro facilities at PDS provide ADME (absorption, distribution, metabolism, excretion) services to provide faster and improved decision making points for our Chemistry clients or standalone offering to support drug discovery programs. We offer cost-efficient standardized and customized assays as per the client’s requirement for ADME parameters. Our ADME capabilities include:

ADME Studies

  • Physicochemical screening
    • Aqueous solubility (Thermodynamic and Kinetic method)
    • Log P (Octanol/water)
    • Log D (Octanol/PBS)
  • Permeability
    • PAMPA
    • CaCo – 2
    • MDCK (wild type)
  • Protein Binding
    • Plasma Protein Binding (Equilibrium Dialysis)
  • Drug Metabolism
    • Hepatocyte Stability
    • Microsomal Stability
    • Plasma Stability
  • Drug-Drug interaction
    • CYP inhibition assays (Fluorescent and LCMS/MS based)